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KMID : 0363319950160010197
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Journal of Korean Oriental Internal Medicine
1995 Volume.16 No. 1 p.197 ~ p.213
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Effects of Sopoongtang on the Cardiovascular System in the Experimental Animals
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Jeong Jang-Kyun
Moon Byung-Soon
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Abstract
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The present experiment was desinged to investigate the effects of Sopungtang water extracts on the Cardiovascular System in the Experimental Animals. Thus, the changes of blood pressure and heart rate were measured after oral administration. Measurments of Mortality rate were observed for measuring the effect of Sopungtang water extract. Sopungtang water extract against pulmonary thromboembolism induced by collagen the mixture(0.1ml/10g, 2mg/kg B.W) plus serotonin(5mg/kg B.W) in mouse. The effects of Sopungtang water extract were examined by observing the change of collagen-induced platelet aggregation, coagulation activity, ex vivo and in vitro fibrinolytic activity of euglobulin fraction in rats.
The results were summarized as followings.
1. Sopungtang dropped the blood pressure in spontaneous hypertensive rat.
2. The drug increased the auricular blood flow in rabbit.
3. The drug relaxed the artery contraction by pretreated norepinephrine in rat.
4. The drug inhibited the death rate of mouse which was led to thromboembolism by serotonin and collagen.
5. The drug inhibited the platelet aggregation in rat.
6. The drug prolonged the prothrombin time and activated partial thromboplastin time on the test of plasma coagulation factor activity in rat, but was not valuable.
7. The drug increased the antithrombin activity in rat and the fibrinogen lyses time was reduced and lyses area was increased.
8. Sopungtang reduced fibrinogen lyses time of rat in vitro assay.
According to the above mentioned results, Sopungtang increased the blood flow and dropped the blood pressure by the dilation of blood vessel. And the drug presented the antithrombin acivity, inhibited the platelet aggregation.
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